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The preceding visit to the cohort took place in , when cohort participants were 18 years old. Giving sequence to the follow-up, the new visit was the first to study the young adulthood period, at the age of 22 years.
The study was expanded to include more detailed assessments of human capital, cognitive function, mental health, cardiovascular assessment, reproductive history and biochemical and genetic characteristics.
Special attention was given to the study of precursors and risk factors for non-communicable diseases NCD which are now the leading cause of death in Brazil 3 and worldwide. Most variables assessed in had also been evaluated in previous follow-ups, 2 and will thus allow the study of trajectories in health status and exposure to risk factors over time. This profile updates earlier descriptions of the cohort. The main focus of the visit at 22 years was described above.
New areas of research, that were not part of the earlier visits, include: mental health e. In addition, blood samples were taken and stored in ultra-low temperature freezers for future biochemical, genetic and epigenetic analyses. Furthermore, during the follow-up at 22 years a sub-study was begun which marks the continuity of intergenerational health research, the first follow-up of the so-called second generation of the cohort 93Cohort-II.
The main objective of this collaboration is to investigate the early determinants of health and nutritional status in childhood, adolescence and adulthood across geographically, culturally and economically distinct regions of the country. Moreover, data from this cohort are part of the Consortium of Health-Oriented Research in Transitioning Societies COHORTS , 9 which aims in particular to strengthen collaboration between five of the largest and longest birth cohort studies in low- and middle-income countries.